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2 in 2011, the us introduced tetanus toxoid. The treatment and prevention of pertussis (whooping cough) infection in infants and children will be discussed here. Infants are at high risk for severe pertussis disease and death, but pertussis rarely causes severe complications among healthy, vaccinated persons

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Pneumonia is the most common complication in all age groups Widespread use of the pertussis vaccine led to a significant decrease in pertussis incidence and mortality. Seizures and encephalopathy are rare and generally occur only among very young infants.

Because immunity to pertussis wanes after either vaccination or natural infection, this disease typically circulates at low levels

More recently, waning immunity has been compounded by decreases in vaccination rates, putting the most vulnerable — the youngest infants — at risk. Despite evidence for lower effectiveness of the third infant dose of acellular pertussis vaccine among maternally vaccinated infants, this was not associated with a higher incidence of pertussis compared with infants with no history of maternal pertussis vaccination. Recent evidence has confirmed a waning of acquired immunity following pertussis immunization or infection, leading to changes in tetanus toxoid, reduced diphtheria toxoid, and acellular. Virtually all pertussis deaths occurred in this age group.

Newborns, especially those under three months old, are at significant risk for severe disease from pertussis due to their immature immune systems and inability to be fully vaccinated. Young infants, in particular, are at greatest risk for severe disease and death caused by pertussis