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This article reports a rare case of amyloidosis of the tongue Biopsy is essential for the. The patient's tongue began to gradually swell and repeatedly ulcerate four years ago, mistaking it for oral ulcers until it affected eating and speech, and was diagnosed with tongue amyloidosis by histopathology.

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Amyloidosis is a rare condition caused by abnormal protein buildup, and it can sometimes affect the tongue, causing symptoms that impact speaking, swallowing, and breathing. In the oral cavity, the tongue is the most common affected site, usually causing macroglossia Oral amyloidosis is secondary to systemic amyloidosis

This means that most often after amyloidosis has spread to multiple organs it affects the mouth

Amyloid proteins will build up in the tissues of the mouth The tongue is the most commonly affected area in oral amyloidosis It can also show up in the gingiva, lip, and palate. Amyloidosis is a condition characterised by abnormal protein deposition the deposition is seen most commonly in the heart, kidney, liver, spleen, and gi tract amyloidosis has an association with macroglossia amyloid deposits in the tongue result in macroglossia

The amyloid deposition was only observed in the tongue, and there was no hematopoietic disease or other diseases that could cause systemic amyloidosis This was the first report of localized amyloidosis of the mobile tongue accompanied with chondroid metaplasia The etiology of this case might be associated with median rhomboid glossitis. Understanding amyloidosis of the tongue is vital due to its implications in diagnosis and treatment of systemic amyloidosis

This condition affects the body's ability to manage protein misfolding, leading to various symptoms that can be subtle yet impactful.

Slightly more males than females with mm are diagnosed with al amyloidosis, except for secondary systemic amyloidosis where incidence is higher in females Al amyloidosis, in both male and female patients, is rarely diagnosed below age 65 years [5, 7, 9] Intraorally, the manifestations of amyloid protein deposits commonly affect the tongue. Amyloidosis is a disease characterized by the progressive deposition of abnormal proteins that can occur in any organ