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This registration process only needs to be completed once The cancer mutation census (cmc) project is an undertaking to classify coding mutations in cosmic and identify variants driving different types of cancer. Please contact us via cosmic@sanger.ac.uk if you encounter any issues.

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This is the cosmic downloads page Open main menu projects cosmic cell lines project cancer mutation census actionability Cosmic mutational signatures is a catalogue of curated reference mutational signatures

Curation covers aetiology, acceptance criteria, tissue distribution and other genomic features of each mutational signature

Downloadable signature profiles and other data are freely available. Cosmic, the catalogue of somatic mutations in cancer, is the world's largest and most comprehensive resource for exploring the impact of somatic mutations in human cancer.