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Genetic disease resistance is usually more important in developing countries, as indigenous breeds possess enhanced resistance to local diseases compared with exotic ones reared in the same environment. There is a genetic component to innate and adaptive immunity, so animals can be bred to resist certain diseases. Much research is dedicated to breeding disease resilient livestock, but this is not yet a common objective in practical breeding programs

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In this paper, we investigate how future breeding programs may benefit from recent research on disease resilience. It is now practised in cattle, sheep, pig, chicken and fish farming. There are numerous reports indicating local breeds as an important reservoir of naturally genetics resistance to disease as a process of adaptability to the environment.

However, for many of the diseases in question, evidence is available in the scientific literature for differential disease resistance or tolerance among livestock breeds (see examples in table 31).

The literature is filled with references of indigenous animals and poultry being resistant to many diseases Keeping this in view, the current review has been written to highlight sustainable and feasible methods for breeding them for disease resistance. In this review, we summarize recent advances in molecular breeding of livestock for disease resistance, focusing on three different breeding strategies for molecular disease resistance. Genetic improvement of economic traits, such as disease resistance, meat production, and meat quality, is the main focus of animal breeding

Through selective breeding and crossbreeding, some economic traits, such as growth and reproduction, have been greatly enhanced over the past several decades. Breeding for disease resistance offers improved animal welfare and increased returns for breeders