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For example, the bucher method has been compared to other itc techniques to evaluate whether both approaches produce mutually consistent results when used to conduct a given treatment comparison. Existing methods use data from patients who have similar traits but received different treatments Comparing two treatments is by essence a causal question [11]

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One common way to formalize this causal effect is the rubin's potential outcomes or counterfactual outcomes framework [12]. Controls and governance over the methodology and reporting of indirect treatment comparisons (itcs) have been introduced to minimize bias and ensure s… Naïve direct comparisons are in most instances inappropriate and should only be used for exploratory purposes and when no other options are possible.